Ipsilateral blepharospasm and contralateral hemidystonia and parkinsonism in a patient with a unilateral rostral brainstem– thalamic lesion: Structural and functional abnormalities studied with CT, MRI, and PET scanning
Identifieur interne : 006681 ( Main/Exploration ); précédent : 006680; suivant : 006682Ipsilateral blepharospasm and contralateral hemidystonia and parkinsonism in a patient with a unilateral rostral brainstem– thalamic lesion: Structural and functional abnormalities studied with CT, MRI, and PET scanning
Auteurs : Leenders [Royaume-Uni] ; R. S. J. Frackowiak [Royaume-Uni] ; N. Quinn [Royaume-Uni] ; D. Brooks [Royaume-Uni] ; D. Sumner [Royaume-Uni] ; C. D. Marsden [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 1986.
English descriptors
- KwdEn :
- Adult, Blepharospasm, Blepharospasm (pathology), Brain Stem (pathology), Computed tomography, Corpus Striatum (metabolism), Dystonia, Dystonia (pathology), Eyelid Diseases (pathology), Humans, Lesion, Magnetic Resonance Imaging, Magnetic resonance imaging, Male, Parkinson Disease (pathology), Parkinson's disease, Positron emission tomography, Receptors, Dopamine (metabolism), Receptors, Dopamine D2, Thalamus (pathology), Tomography, Emission-Computed, Tomography, X-Ray Computed.
- MESH :
- chemical , metabolism : Receptors, Dopamine.
- metabolism : Corpus Striatum.
- pathology : Blepharospasm, Brain Stem, Dystonia, Eyelid Diseases, Parkinson Disease, Thalamus.
- Adult, Humans, Magnetic Resonance Imaging, Male, Receptors, Dopamine D2, Tomography, Emission-Computed, Tomography, X-Ray Computed.
Abstract
A patient developed progressive right hemidystonia in childhood. Subsequently, left‐sided blephaospasm, slurred and stuttering speech, and right‐sided rigidity and bradykinesia, responsive to dopamine agonists, appeared. Investigation with computed tomography and magnetic resonance imaging (MRI) at age 43 years revealed a left‐sided calcified rostral brainstem‐thalamic lesion of uncertain aetiology. Although no structural lesion was seen in the striatal regions, L‐[18F]‐fluorodopa uptake was severely diminished in the left striatum but normal on the right. Dopamine receptor binding identified by [11C]‐methylspiperone was in the normal range on both sides.
Url:
DOI: 10.1002/mds.870010107
Affiliations:
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Le document en format XML
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<term>Brain Stem (pathology)</term>
<term>Computed tomography</term>
<term>Corpus Striatum (metabolism)</term>
<term>Dystonia</term>
<term>Dystonia (pathology)</term>
<term>Eyelid Diseases (pathology)</term>
<term>Humans</term>
<term>Lesion</term>
<term>Magnetic Resonance Imaging</term>
<term>Magnetic resonance imaging</term>
<term>Male</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson's disease</term>
<term>Positron emission tomography</term>
<term>Receptors, Dopamine (metabolism)</term>
<term>Receptors, Dopamine D2</term>
<term>Thalamus (pathology)</term>
<term>Tomography, Emission-Computed</term>
<term>Tomography, X-Ray Computed</term>
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<term>Dystonia</term>
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<front><div type="abstract" xml:lang="en">A patient developed progressive right hemidystonia in childhood. Subsequently, left‐sided blephaospasm, slurred and stuttering speech, and right‐sided rigidity and bradykinesia, responsive to dopamine agonists, appeared. Investigation with computed tomography and magnetic resonance imaging (MRI) at age 43 years revealed a left‐sided calcified rostral brainstem‐thalamic lesion of uncertain aetiology. Although no structural lesion was seen in the striatal regions, L‐[18F]‐fluorodopa uptake was severely diminished in the left striatum but normal on the right. Dopamine receptor binding identified by [11C]‐methylspiperone was in the normal range on both sides.</div>
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